A Proposition of Including Intradermal Injections with A Non-Specific Antigen Preparation

Journal of General Medcicine and Primary care

Short Communication

A Proposition of Including Intradermal Injections with A Non-Specific Antigen Preparation in Primary Cares of Allergic Diseases

Kimihiko Okazaki1*
1Department of Immunology, Okazaki Medical Clinic Ukyoku, Japan
*Corresponding author: Kimihiko Okazaki, Okazaki Medical Clinic Ukyoku, Kyoto, Japan; E-mail:
Received: July 11, 2017; Accepted: July 15, 2017; Published: July 22, 2017
Copyright: ©2017 Okazaki K. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation: Okazaki M (2017) A Proposition of Including Intradermal Injections with A Non-Specific Antigen Preparation in Primary Cares of Allergic Diseases. J Gen Med Prim Care 1(1): 100001.

View PDF Download PDF

Short Communication

The so-called routine procedures of primary care for allergic diseases that are currently carried out are prescriptions of anti-allergic medicines. On the other hand, a novel concept concerning existence of equilibrium states among antibody molecules in the vicinity of the receptors was proposed as early as in 1959 [1] and has been established around the end of the twentieth century [2-11]. It is evident that another novel concept can be deduced from the concept mentioned above. Namely, antibody molecules’ mutual exchanges are occurring all the time. In more detail, all of antibody molecules in the vicinity of the receptors keep attaching to and detaching from the receptors. In other words, antibodies’ replacements are occurring all the time. In addition, if allergen-specific antibodies were replaced by non-specific antibodies, causes of allergic diseases would be eliminated. It is obvious that elimination of cause of disease is an ideal treatment. In addition, the ideal treatment can be carried out extremely easily. In more detail, all you need to do is to inject your patient intradermally with a non-specific antigen preparation. Further explanation would be that the injected non-specific antigen will force the patient produce non-specific antibodies, which in turn replace allergen-specific antibodies from the surface of mast cells. An example of non-specific antigen preparation is Neurotropin, a product of Nippon Pharmaceutical Company, LTD(Osaka) consisting of extracts of rabbit skin inflamed by inoculation of Vaccinia virus.


  1. Porter RR (1959) The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J 73: 119-126.
  2. Stanworth DR, Humphrey JH, Bennich H and Johansson SGO (1967) Specific inhibition of the Prausnitz-Kuestner reaction by an atypical human melanoma protein. Lancet: 330-332.
  3. Ogawa M, McIntyre OR, Ishizaka K, Ishizaka T, Terry WD, et al. (1971) Biologic properties of E myeloma proteins. Am J Med 51: 193-199.
  4. Ishizaka T, Soto CS, Ishizaka K (1973) Mechanisms of passive sensitization III. Number of IgE molecules and their receptor sites on human basophil granulocytes. J Immunol 111: 500-511.
  5. Bazaral M, Orgel HA, Hamburger RN (1973) The influence of serum IgE levels of selected recipients, including patients with allergy, Helminthiasis and tuberculosis, on the apparent P-K titre of a reaginic serum. Clin Exp Immunol 14: 117-125.
  6. Godfrey RC (1975) Asthma and IgE levels in rural and urban communities of The Gambia. Clin Allergy 5: 201-207.
  7. Knapp W, Majdic O, Holter W, Stockinger H, Köller U (1985) [Considerations on the therapeutic use of monoclonal antibodies]. Wien Klin Wochenschr 97: 97-107.
  8. Haessig A (1986) Intravenous immunoglobulins: pharmacological aspects and therapeutic use. Vox Sang 51: 10-17.
  9. De Simone C, Delogu G, Corbetta G (1988) Intravenous immunoglobulins in association with antibiotics: a therapeutic trial in specific intensive care unit patients. Crit Care Med 16: 23-26.
  10. Rakestraw SL, Ford WE, Tompkins RG, Rodgers MA, Thorpe WP, et al. (1992) Antibody-targeted photolysis: in vitro immunological, photophysical, and cytotoxic properties of monoclonal antibody-dextran-Sn(IV) chlorin e6 immunoconjugates. Biotechnol Prog 8: 30-39.
  11. Nydegger UE, Mohacsi PJ, Escher R, Morell A (2000) Clinical use of intravenous immunoglobulins. Vox Sang 78 Suppl 2: 191-195.